E-Cigarette Nicotine Delivery Among Young Adults…
Cho YJ, et al. E-Cigarette Nicotine Delivery Among Young Adults by Nicotine Form, Concentration, and Flavor: A Crossover Randomized Clinical Trial.
JAMA Netw Open..9 August 2024;7(8):e2426702. doi:10.1001/jamanetworkopen.2024.26702
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822152
“In this crossover randomized clinical trial of 72 participants aged 21 to 25 years who used e-cigarettes, salt-based (vs freebase) nicotine resulted in higher nicotine intake after both 5-minute standardized and 30-minute ad libitum vaping, particularly at 5% (vs 1%) nicotine. Compared with freebase nicotine, nicotine salts yielded more positive subjective effects ratings and intense puffing behaviors, and menthol (vs tobacco) flavor yielded more positive subjective effects ratings.
The findings imply that salt-based nicotine formulations prevalent in the market may increase nicotine dependence among young adults already using e-cigarettes and warrant regulation.
Comment: Common salt-based and menthol-flavored formulations of e-cigarettes tend to “increase nicotine dependence among young adults.”
Stephen Hamann
